Role of Cytokines in Pathophysiology of Sickle Cell Disease

Abstract

Pathophysiology of vaso-occlusive crisis in sickle cell disease is a complex process. A rapidly growing body of evidence implies the presence of a cytokine regulatory pathway related to RBC adherence to endothelial cell. Our preliminary work suggests the presence of abnormal levels of some cytokines in sickle cell patients. Prior to exploring the role of cytokines in the pathophysiology of VOC in sickle cell disease, we would like to have a more solid documentation.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR005280-08
• Application #: 2355228
• Budget Start: 1995-10-01
• Budget End: 1996-09-30
• Support Year: 8
• Fiscal Year: 1996

Institution

• Name: University of Miami School of Medicine
• City: Miami
• State: FL
• Country: United States
• Zip Code: 33146

Publications

Puhan, Milo A; Ahuja, Alka; Van Natta, Mark L et al. (2011) Interviewer versus self-administered health-related quality of life questionnaires - does it matter? Health Qual Life Outcomes 9:30

Puhan, Milo A; Van Natta, Mark L; Palella, Frank J et al. (2010) Excess mortality in patients with AIDS in the era of highly active antiretroviral therapy: temporal changes and risk factors. Clin Infect Dis 51:947-56

Rimrodt, Sheryl L; Peterson, Daniel J; Denckla, Martha B et al. (2010) White matter microstructural differences linked to left perisylvian language network in children with dyslexia. Cortex 46:739-49

Johnson, Andrew D; Yanek, Lisa R; Chen, Ming-Huei et al. (2010) Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet 42:608-13

Wilkin, Timothy J; Su, Zhaohui; Krambrink, Amy et al. (2010) Three-year safety and efficacy of vicriviroc, a CCR5 antagonist, in HIV-1-infected treatment-experienced patients. J Acquir Immune Defic Syndr 54:470-6

Gluckman, T J; Segal, J B; Schulman, S P et al. (2009) Effect of anti-platelet factor-4/heparin antibody induction on early saphenous vein graft occlusion after coronary artery bypass surgery. J Thromb Haemost 7:1457-64

Cole, W R; Mostofsky, S H; Larson, J C Gidley et al. (2008) Age-related changes in motor subtle signs among girls and boys with ADHD. Neurology 71:1514-20

Froud, Tatiana; Faradji, Raquel N; Pileggi, Antonello et al. (2008) The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects. Transplantation 86:36-45

Jabs, Douglas A; Van Natta, Mark L; Holbrook, Janet T et al. (2007) Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment. Ophthalmology 114:780-6

Jabs, Douglas A; Van Natta, Mark L; Holbrook, Janet T et al. (2007) Longitudinal study of the ocular complications of AIDS: 2. Ocular examination results at enrollment. Ophthalmology 114:787-93