Abstract

This study aims to reverse hyperglycemia and insulin dependence in patients with insulin requiring diabetes mellitus by islet cell transplantation and to elevate the effect of normalization or improvement of glucose metabolism in patients with non-insulin dependent diabetes mellitus receiving a combined kidney/islet transplant. We will also assess long-term function of successful islet cell transplants in patients with insulin requiring diabetes mellitus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR005280-08
Application #
5225008
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Puhan, Milo A; Ahuja, Alka; Van Natta, Mark L et al. (2011) Interviewer versus self-administered health-related quality of life questionnaires - does it matter? Health Qual Life Outcomes 9:30
Puhan, Milo A; Van Natta, Mark L; Palella, Frank J et al. (2010) Excess mortality in patients with AIDS in the era of highly active antiretroviral therapy: temporal changes and risk factors. Clin Infect Dis 51:947-56
Rimrodt, Sheryl L; Peterson, Daniel J; Denckla, Martha B et al. (2010) White matter microstructural differences linked to left perisylvian language network in children with dyslexia. Cortex 46:739-49
Johnson, Andrew D; Yanek, Lisa R; Chen, Ming-Huei et al. (2010) Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet 42:608-13
Wilkin, Timothy J; Su, Zhaohui; Krambrink, Amy et al. (2010) Three-year safety and efficacy of vicriviroc, a CCR5 antagonist, in HIV-1-infected treatment-experienced patients. J Acquir Immune Defic Syndr 54:470-6
Gluckman, T J; Segal, J B; Schulman, S P et al. (2009) Effect of anti-platelet factor-4/heparin antibody induction on early saphenous vein graft occlusion after coronary artery bypass surgery. J Thromb Haemost 7:1457-64
Cole, W R; Mostofsky, S H; Larson, J C Gidley et al. (2008) Age-related changes in motor subtle signs among girls and boys with ADHD. Neurology 71:1514-20
Froud, Tatiana; Faradji, Raquel N; Pileggi, Antonello et al. (2008) The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects. Transplantation 86:36-45
Jabs, Douglas A; Van Natta, Mark L; Holbrook, Janet T et al. (2007) Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment. Ophthalmology 114:780-6
Jabs, Douglas A; Van Natta, Mark L; Holbrook, Janet T et al. (2007) Longitudinal study of the ocular complications of AIDS: 2. Ocular examination results at enrollment. Ophthalmology 114:787-93

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