We will test the hypothesis that the therapies currently employed to treat childhood leukemias and lymphomas (systemic/intrathecal chemotherapy and lwo-dose, 1800cGy, cranial radiation) cause damage to the neuroregulatory centers int he brain responsible for the sex steroid mediated increase in growth hormone production. As a consequence, these individuals produce normal amounts of GH in the prepubertal years but fail to demonstrate the expected increase in GH concentration in response to sex steroids (both endogenous and exogenous).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR006020-09A1
Application #
6122557
Study Section
Project Start
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
9
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
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