This study focuses on the evaluation of a traditional treatment, viz., thiamine or vitamin B2, administered to a nontraditional population, i.e., alcoholic patients without Wernicke-Korsakoff's Syndrome. The principal aim of the study is to examine the potentially beneficial effects of a 5 gram oral dose of thiamine versus a matching placebo on the cognitive status of alcohol-dependent patients (n=20) and normal non-drug-dependent volunteers (n=15). Thiamine or placebo is administered (in counterbalanced order)on consecutive days. It is hypothesized that the patients with histories of alcohol dependence will benefit more from thiamine therapy. The study is ongoing with additional data collection expected.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Type
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030
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Litt, Mark D; Duffy, Valerie; Oncken, Cheryl (2016) Cigarette smoking and electronic cigarette vaping patterns as a function of e-cigarette flavourings. Tob Control 25:ii67-ii72
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