Abstract

Aim 1: To obtain clinical parameters of disease activity, biochemical markers of bone turnover and serum levels of selected cytokines (IL-6, IL-1b, TNF-a) in patients with inflammatory bowel disease (IBD). These variables will then be individually correlated with bone density to find which patients are at increased risk for osteopenia. The clinical measurements will be followed prospectively over a period of 2 years at 6-month intervals. These data will complement and expand the limited available information on bone homeostasis in children with Crohn's disease (CD). Sera from these patients will be used for basic laboratory experiments (Aim 2).
Aim 2 : To determine which cytokines in the serum from CD are involved in decreasing bone formation. Antibodies to specific cytokines (IL-6, IL-1b, TNF-a) will be applied to the mineralizing organ culture system to block the inhibition of calcification and assess which cytokines are causing bone alterations. Havingt identified the candidate cytokines by this approach, we will add each candidate cytokine in clinically relevant concentrations to the organ culture system and to an osteoblast cell culture system to confirm their role in osteopenia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR006192-07
Application #
6309857
Study Section
Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
7
Fiscal Year
2000
Total Cost
$19,111
Indirect Cost

  Institution

Name
University of Connecticut
Department
Type
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2018) Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol 66:45-53
Usmani, Saad; Choquette, Linda; Bona, Robert et al. (2018) Transient bacteremia induced by dental cleaning is not associated with infection of central venous catheters in patients with cancer. Oral Surg Oral Med Oral Pathol Oral Radiol 125:286-294
Moscufo, Nicola; Wakefield, Dorothy B; Meier, Dominik S et al. (2018) Longitudinal microstructural changes of cerebral white matter and their association with mobility performance in older persons. PLoS One 13:e0194051
Santos-Cortez, Regie Lyn P; Hu, Ying; Sun, Fanyue et al. (2017) Identification of ASAH1 as a susceptibility gene for familial keloids. Eur J Hum Genet 25:1155-1161
Jin, Lingling; Liu, Yi; Sun, Fanyue et al. (2017) Three novel ANO5 missense mutations in Caucasian and Chinese families and sporadic cases with gnathodiaphyseal dysplasia. Sci Rep 7:40935
Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2017) Examining FKBP5 mRNA expression in human iPSC-derived neural cells. Psychiatry Res 247:172-181
Litt, Mark D; Duffy, Valerie; Oncken, Cheryl (2016) Cigarette smoking and electronic cigarette vaping patterns as a function of e-cigarette flavourings. Tob Control 25:ii67-ii72
Rash, Carla J; Burki, Madison; Montezuma-Rusca, Jairo M et al. (2016) A retrospective and prospective analysis of trading sex for drugs or money in women substance abuse treatment patients. Drug Alcohol Depend 162:182-9
Walter, Kimberly N; Petry, Nancy M (2016) Lifetime suicide attempt history, quality of life, and objective functioning among HIV/AIDS patients with alcohol and illicit substance use disorders. Int J STD AIDS 27:476-85
Litt, Mark D; Kadden, Ronald M; Tennen, Howard et al. (2016) Network Support II: Randomized controlled trial of Network Support treatment and cognitive behavioral therapy for alcohol use disorder. Drug Alcohol Depend 165:203-12

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