This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.A. 1.
Specific Aims :To study the effect of aripiprazole on behavioral effects (i.e., sedative/hypnotic, anxiolytic, stress-reducing properties) and physiological effects (i.e., blood pressure, heart rate, psychomotor task performance) of a moderate dose of alcohol in 20 healthy subjects with no history of alcohol abuse or dependence. Genetic analysis will also provide preliminary information on allelic association both to alcohol response in healthy individuals and as control data for studies of individuals affected with alcohol and/or drug dependence. 2. Hypothesis:Aripiprazole is a new atypical antipsychotic with a unique receptor binding profile that combines partial agonist activity at D2 and 5-HT1A receptors and potent antagonism at 5-HT2A receptors. Based on this profile of activity, we hypothesize that aripiprazole will reduce the pleasurable, stimulating, and anxiolytic effects of alcohol, but not its effects on blood pressure and heart rate. An evaluation of this hypothesis may help to elucidate the neuropsychopharmacology of alcohol and may suggest a novel approach to the pharmacotherapy of alcohol dependence.
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