This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Oral candidiasis is perhaps the most frequent opportunistic infection associated with an immunocompromised host. The most important immune cell type in the defense against Candida is the neutrophil (PMN). Although these cells are considered important in the resistance to and eradication of fungi, expression of these functions requires activation by soluble proteins known as cytokines. In the immunocompromised host these molecules are more likely to be derived from cells of non-immune origin, such as epithelial cells. The purpose of this study is to test the activation of neutrophil anti-fungal functions in response to cytokines secreted by oral epithelial cells.
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