RSR13 is a synthetic allosteric modifier of hemoglobin. It reduces hemoglobin-oxygen binding affinity and enhances the diffusion of oxygen from the blood to the tissues. Hypoxic conditions are present in tumors. This may be a major cause of treatment failure since hypoxic cells are substantially more resistant to radiation than oxygenated cells. RSR13 may decrease these hypoxic conditions, thereby increasing the efficacy of radiation treatment. We are proposing a phase II study to evaluate the efficacy and safety of RSR13 combined with cranial irradiation in the treatment of brain metastasises.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR007122-09
Application #
6408625
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1992-09-30
Project End
2001-02-28
Budget Start
Budget End
Support Year
9
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
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