This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to describe the change in renovascular disease (i.e. kidney artery narrowing or blockage) among free-living elderly Americans. Participants from the Forsyth County cohort of the Cardiovascular Health Study (CHS) will be invited to participate. Between January 1995 and February 1997, 870 Forsyth County CHS participants were evaluated with renal duplex sonography (RDS) as part of an ancillary study funded through the NIDDK (1R01DK47414). That study provided the first population-based estimates of prevalence for renovascular disease (RVD) among the elderly. Moreover, the cohort provides a unique sample of previously studied participants for re-evaluation to describe both newly occurring renovascular disease and the anatomic progression of established disease. All active Forsyth County CHS participants will be contacted by telephone and invited to undergo repeat RDS examination. From the results, estimates of incident renovascular disease as well as information concerning the progression of pre-existing disease will be obtained.
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