This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infection severe enough to cause low blood pressure is an inflammatory state which is called severe sepsis. Patients with severe sepsis can have adrenal gland failure. Adrenal gland insufficiency is believed to lead to low blood pressure (shock). ACTH is a hormone that has been used to test adrenal function. Currently, it is unclear from the medical literature which dose of ACTH to use to evaluate adrenal function. To find the best dose, several FDA-approved doses of ACTH will be given when the severe sepsis patient is in (1) shock, (2) immediately after recovery from shock, and (3) then again as an outpatient. We will test whether there is a genetic predisposition to develop shock.
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