This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.While cross-sectional studies show that drug abuse, impulsivity, serotonin dysregulation, and stressful life events are associated with suicide, studies examining the specific relationships of these factors are limited. A NIDA-sponsored workgroup was formed to identify gaps in the literature and priorities for future research. Studies have typically related individual measures of impulsivity or serotonin (5-HT) markers to self reports of previous suicidal behaviors and drug abuse cross-sectionally, but they have not determined the predictive validity of these measures in determining future drug abuse and suicidal behaviors. Furthermore, the relationships between impulsive behavior and 5-HT, while often included in theoretical models of suicide, have not been firmly established. Also, how the combination of factors defined within these models affects the developmental trajectories of drug abuse and suicidal behaviors is unknown. The purpose of this longitudinal study is to examine the interrelationships among impulsivity, 5-HT, stressful life events, and the dual outcomes of drug use and different types of suicidality in high-risk adolescents. Our goal is to determine the direct and interactive contributions of these factors to the developmental trajectories of suicidal behavior and drug abuse.
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