This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The BMDCS is a 3-year longitudinal study of bone mass accretion in an ethnically diverse cohort of 1530 healthy children and adolescents between 6 and 16 years of age at enrollment. The goal of the BMDCS is to obtain pediatric standards for bone mineralization by dual energy x-ray absorptiometry (DXA) in relation to age, body size, skeletal development and sexual maturation. Longitudinal measures of bone mineralzation will be obtained so that normal ranges of bone mineral accrual through childhood and adolescence can be established. Subjects will be recruited over a 12-month period at five clinical centers in the U.S.: Columbia University, Children's Hospital of Philadelphia, Cincinnati Children's Hospital, Creighton University, and Children's Hospital, Los Angeles. Children will be enrolled in the study after a detailed screening to ensure that they have normal growth and maturation and are free of factors known to affect bone mineralization. Bone mass and density will be measured by DXA at baseline and then annually for three years. DXA scans will be obtained of the total body, left hip, lumbar spine and non-dominant forearm. A hand wrist x-ray for bone age determination and detailed measurements of growth and pubertal maturation will be obtained in conjunction with the DXA measurements. Information on physical activity, dietary intake and general health also will be obtained at each visit.
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