This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Type 1 Diabetes Genetics Consortium (T1DGC) is a collaborative effort looking to undertake molecular genetic studies to identify individual genes that determine an individual's risk of or protection from type 1diabetes. The study's objectives are: 1) to obtain, study, and establish a renewable source of DNA on 3,000 families worldwide with at least 2 siblings with type 1 diabetes, their parents, and up to 2 siblings without diabetes for studies to identify genes that affect the risk for type 1 diabetes; 2) to create a database for the scientific community with clinical, genetic and medical history information that will facilitate the search for genes that make one susceptible to type 1 diabetes; 3) to provide a central DNA repository to allow targeted studies of genetic structure and function for type 1 diabetes; and 4) to evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention, and therapy in the area of type 1 diabetes. Once a family has been identified, and deemed eligible, study information is mailed and followed by phone calls to determine their interest level. If a family is interested, an appointment is scheduled. Questionnaires are completed regarding information on demographics, and family health history. The consent is discussed and signed. Blood samples are obtained from each participant. blood is collected for future diabetic testing, production of a DNA cell line, and diabetes antibodies on the siblings with diabetes.
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