This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will begin a detailed study of insulin resistance, beta cell function, anthropometrics, nutrition, and physical activity in morbidly obese adults compared to adolescents undergoing bariatric surgery in relation to carbohydrate metabolism. While it is known that gastric bypass causes the weight loss necessary to correct some metabolism problems, not much is known about when these changes need to happen to provide the best long term outcome. Evidence suggests that if left untreated for too long the pancreas can 'burn out' and then the metabolism problems may be less completely reversed. The effects of gastric bypass on the metabolism of adults and adolescents will be compared to try to determine whether there are greater metabolic and health advantages of performing gastric bypass earlier in life versus waiting until adulthood.
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