This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Prepubertal African-American girls are not heavier than white girls, but racial divergence in adiposity evolves sometime during adolescence. The reasons for the high prevalence of obesity in AA women, and the racial disparity in secular trends, remain poorly understood. The purpose of this study was to examine the association of UCP3 polymorphism with variation in resting energy expenditure (REE). The first hypothesis was that those women with the C/C genotype will manifest REE levels which are significantly lower than those with the T/T genotype. There will be a significant trend toward lower REE levels across UCP3 genotypes with C/C homozygotes manifesting the lowest, T/T homozygotes manifesting the highest, and C/T heterozygotes manifesting intermediate levels of REE. The next hypothesis was to examine the association of the UCP3 polymorphism with variation in fat mass; those females with the C/C genotype will manifest levels of fat mass which are significantly higher than those with the T/T genotype. The third hypothesis was to determine whether the effects of UCP3 and the effects of 3AR are independent of each other by examining the effects of one genotype (e.g. UCP3) within a given genotype of the second locus (e.g. b3AR Trp/Trp and b3AR Trp/Arg). There is a synergistic effect between the UCP3 and the 3AR codon 64 polymorphisms with the lowest REE levels occurring among those who are UCP3 C/C and b3AR Trp/Arg as compared to b3AR Trp/Trp, and fat mass will be highest among those who are UCP3 C/C and b3AR Trp/Arg.
Showing the most recent 10 out of 502 publications
