This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This project is designed to study the regulation of insulin secretion by hormones secreted from the intestine. To date we have performed two experiments as part of this project. In the first we assessed the reproducibility of 'intestinally driven' insulin secretion and measured the dependence of this process on blood glucose levels. We determined that the day-to-day variability of gut hormones to insulin secretion after a meal is < 15% and is relatively constant at blood glucose levels of 150 and 190 mg/dl. In the second experiment we determined the contribution of the GI hormone glucagon-like peptide 1 (GLP-1) to meal induced insulin secretion in adults with type 2 diabetes and a group of nondiabetic subjects matched for age and weight. In this study we found that the contribution of GLP-1 was 30-40% and did not differ in the diabetic and control subjects. The work to date emphasizes the key role of GI hormones in regulating glucose and shows that in diabetic patients this effect is retained.
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