This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Purpose of Aim 2 Effect of diet and fiber content on Equol Production in Adults The purpose of this study is to determine whether a person's typical daily diet determines whether they are able to convert the isoflavone daidzein to the metabolite equol when they eat soy protein. Numerous small studies suggest that the frequency of 'equol-producers' is highly variable among different population groups, pointing to the likelihood of diet being an important factor in equol production. This contention is reinforced by recent suggestions that equol production is more frequent in people consuming a higher proportion of daily calories as carbohydrate or a lower proportion as saturated fat. We will test these hypotheses in healthy adults from omnivore (mixed-diet) and vegetarian groups stratified into low, medium and high dietary fiber intake as determined by the NCI Dietary History Questionnaire and 3 day diet diary.
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