Risk-factor reduction has become an acceptable approach to cardiovascular disease (CVD) prevention/treatment. The results of clinical trials have demonstrated the effectiveness of programs in this area in reducing body size (% of body weight, girth, skinfolds thickness), blood pressure (BP), blood glucose, and serum lipids (total cholesterol, LDL-cholesterol, triglycerides). Through a cohort of at least 50 black females, ages 18- 75, with obesity as one of the CVD risk factors, this study will meet the following objectives: 1) Determine the effectiveness of a specially-designed, culturally sensitive life-style change program in CVD risk reduction; 2) Demonstrate the feasibility of a fat modified diet in reducing serum lipids, blood glucose, BP, and body size; 3) Examine the relationship between exercise and serum lipid fractions, particularly HDL. Using a prospective study design, subjects will undergo baseline measurement of medical and dietary data. The study period will include an initial; screening visit, a complete CVD risk factor evaluation, followed by an intense eight (8) month intervention period, and a post intervention evaluation. Subjects will attend bi-weekly exercise/fitness seminars along with weekly lectures, individual and group counseling sessions, and bi-monthly food-related activities (cooking demonstrations, grocery store tours, recipe testings, and dining-out seminars).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
1M01RR010284-01A1
Application #
5225846
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Christensen, Kurt D; Uhlmann, Wendy R; Roberts, J Scott et al. (2018) A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone. Genet Med 20:132-141
Doumatey, Ayo P; He, William J; Gaye, Amadou et al. (2018) Circulating MiR-374a-5p is a potential modulator of the inflammatory process in obesity. Sci Rep 8:7680
Guan, Yue; Roter, Debra L; Wolff, Jennifer L et al. (2018) The impact of genetic counselors' use of facilitative strategies on cognitive and emotional processing of genetic risk disclosure for Alzheimer's disease. Patient Educ Couns 101:817-823
Mullins, Tanya L Kowalczyk; Li, Su X; Bethel, James et al. (2018) Sexually transmitted infections and immune activation among HIV-infected but virally suppressed youth on antiretroviral therapy. J Clin Virol 102:7-11
Faruque, Mezbah U; Chen, Guanjie; Doumatey, Ayo P et al. (2017) Transferability of genome-wide associated loci for asthma in African Americans. J Asthma 54:1-8
Guan, Yue; Roter, Debra L; Erby, Lori H et al. (2017) Disclosing genetic risk of Alzheimer's disease to cognitively impaired patients and visit companions: Findings from the REVEAL Study. Patient Educ Couns 100:927-935
Nandakumar, Priyanka; Lee, Dongwon; Richard, Melissa A et al. (2017) Rare coding variants associated with blood pressure variation in 15?914 individuals of African ancestry. J Hypertens 35:1381-1389
Lieberman, Richard; Armeli, Stephen; Scott, Denise M et al. (2016) FKBP5 genotype interacts with early life trauma to predict heavy drinking in college students. Am J Med Genet B Neuropsychiatr Genet 171:879-87
Christensen, Kurt D; Roberts, J Scott; Whitehouse, Peter J et al. (2016) Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial. Ann Intern Med 164:155-63
Armeli, Stephen; O'Hara, Ross E; Covault, Jon et al. (2016) Episode-specific drinking-to-cope motivation and next-day stress-reactivity. Anxiety Stress Coping 29:673-84

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