This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Glaucoma is a group of diseases characterized by progressive damage of the optic nerve and irreversible loss of vision. One of the most prevalent forms is primary open angle glaucoma (POAG) with approximately 33.1 million sufferers around the world. Early treatment for individuals suspected of having glaucoma and for those with early glaucoma slow the progression of the disease; thus, a major goal of glaucoma research is identifying individuals at high-risk for glaucoma for intense monitoring and early treatment. Identifying genes associated with developing glaucoma is a potential component of early risk detection.This is a study designed to 1) identify genes and genetic variations within the genes which cause glaucoma and 20 identify the clinical features associated with these genetic variations. It will include 1500 African Americans from Howard University eye clinics, 1000 with primary open angle glaucoma (POAG) and 500 as controls as well as 10 multiple case families. Patients will receive a comprehensive eye examination, eye pressure assessment, retinal tomography and optical coherence tomography. Blood samples will be stored in the HU Biobank and transported to University of Iowa for gene screen and linkage analysis.
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