This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.African-American[AA] men have the highest incidence of prostate cancer in the world. The exact cause is unknown. However, a diet high in fat and/or a sedentary lifestyle may predispose AA men to prostate cancer by affecting levels of serum factors such as free testosterone, sex hormone-binding globulin [SHBG],insulin, insulin-like growth factor-1 [IGF1], prostate-specific antigen [PSA], and insulin-like growth factor binding proteins-2 and 3. A total 40 AA men between the ages of 40-70 yrs, from the Howard University Cancer Center prostate screening program that have a PSA between 2.5-3.9 ng/ml, a BMI > 25 and <35Kg/m2, and have been sedentary for at least 2 years [not exercising fro more than 20 minutes 2 days a week]. The men will be randomized into 2 group 12 days of aerobic exercise [20 participants] or a control group[20 participants]. All participants will be screened by a physician for cardiovascular disease and participate a 12 days of exercise which will consist of 30 minutes of walking on a treadmill at 50-60% of maximal heart rate reserve. Participants will also complete a 3-day food record (two weekdays and one weekend day) to estimate diet composition. Blood samples will be taken in the morning after an overnight fast on day1, and day 13, 24-36 hours after the last bout of exercise. Serum will be stored at -80oC until analyzed. Free testosterone, lipids, glucose, insulin, SHBG, body weight, BMI and body fat, anthropometric measurements will be measured before and after the study.
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