This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The problem of emotional arousal and its cognitive consequences not only has short-term,sometimes irreversible ,neuro-toxic effects on the brain. These potential effects of stress need to be better understood both to minimize risk,as well as eventually to develop better treatment for damage that has already occurred. This study constitutes a critical first step in investigating both short and long-term effects of stress reactivity, using an inter-disciplinary approach combined with state of the art technology, to establish much needed norms on human performance and neurological function under arousal. The primary aims of this study are to: a) examine variability between individuals on neural,cardiac,and endocrine measures of stress reactivity; b) to investigate whether,for each individual,physiological stress reactivity accurately predicts that individual's cognitive resilience to arousal,as measured by pre-attentive and attentive utilization of relevant cues and screening of irrelevant cues; and c) to elucidate the role of compensatory neural mechanisms in those individuals who are most efficient at ameliorating the cognitive and physiological effects of arousal.
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