There is a concern by some who use chlorine in chemical production facilities that there is an occupational hazard of inhaled chlorine. The purpose of this project is to determine the distribution of inhaled CL2 in healthy men and women during oral and nasal breathingat respiratory flows characteristic of rest and exercise.
The specific aims are: Develop a bolus inhalation method to safely and indirectly measure Cl2 distribution in the respiratory tract. This method will be tested on 3-5 subjects who are breathing quietly through their nose. Determine the effect of different inhalation concentrations from 0.3 to 3.0 parts per million on the Cl2 distribution in a group of five subjects who are breathing quietly through their nose. Determine the change in Cl2 distribution during oral breathing when respiratory flow increases from a resting level to a level characteristic of light exercise in a group of ten subjects who are breathing through their nose. (The subjects will not be exercising) Determine whether a change from nasal to oral breathing increases the fraction of inhaled Cl2 that reaches the lower airways in a group of ten subjects who are breathing quietly.
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
| Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208 |
| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917 |
| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Sterling, Nicholas W; Wang, Ming; Zhang, Lijun et al. (2016) Stage-dependent loss of cortical gyrification as Parkinson disease ""unfolds"". Neurology 86:1143-51 |
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