ARDS s a syndrome with a 50% mortality. Current therapy for ARDS is treatment of the underlying precipitating disease or event, supportive care and avoiding complications. Patients are usually managed in the supine position, but there are several case series that suggest the prone position may improve oxygenation in mechanically ventilated (MV) patients with ARDS (78% out of 87 patients had improvement in oxygenation). This may be due to changes in regional lung inflation, redistribution of perfusion or changes in transpulmonary pressure gradients. Baseline data is recorded. The patient is then turned to the prone position and arterial blood gases are done twice post turning as well as collection of pulmonary artery (PA) catheter and MV data. The MV may be adjusted and the patient returned to the supine position if needed to maintain oxygenation. Patients who desaturate will be returned to the supine position and retried in the prone position 24 hours later. Patients who have improvement will remain in the prone position for 24 hours at which time they will be returned to the supine position. Blood gases and data collection will be done 4 times in the prone position and 2 times in the supine position. Other supportative care continues, including repositioning every 2 hours. If oxygenation worsens or does not improve the patient exits the study. The patient also exits the study if the investigator thinks the prone position is compromising care, dialysis or vasopressors are needed or a tracheostomy is done.
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
| Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208 |
| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917 |
| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Quick, Virginia; Byrd-Bredbenner, Carol; Shoff, Suzanne et al. (2016) Relationships of Sleep Duration With Weight-Related Behaviors of U.S. College Students. Behav Sleep Med 14:565-80 |
Showing the most recent 10 out of 645 publications
