Preliminary studies suggest that limb congestion may augment sympathetic nerve responses even more in the aged than in younger subjects. This is important since edema is a common clinical problem in the aged. In these studies, we will compare two study groups. We will contrast the effects of limb congestion sympathetic nerve responses to forearm exercises in a group of young and a group of old normal subjects. Each subject will perform two bouts of static handgrip exercise, with and without precongesting the forearm. We postulate that static exercise will evoke an increase in muscle sympathetic nerve activity (MSNA) in both subject groups. We further postulate that during a period of post-handgrip circulatory arrest (PHG-CA), sympathetic nerve traffic will remain elevated in both groups. In addition, we postulate that limb venous congestion will augment sympathetic nerve traffic in both groups during exercise but will have no effect on the MSNA response seen during PHG-CA. Based on our pilot data, we suspect that elderly individuals will have dramatic augmentation in MSNA in response to the venous congesting maneuver. Some subjects who do not have an increase in MSNA with exercise will have almost a 'normal' response after the forearm is congested
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
| Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208 |
| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917 |
| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Lewis, Mechelle M; Flynn, Michael R; Lee, Eun-Young et al. (2016) Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders. Neurotoxicology 57:39-44 |
Showing the most recent 10 out of 645 publications
