Exercise normally causes activation of a portion of the body's reflex nervous system called the 'sympathetic' nervous system, which results in increased heart rate and blood pressure. The mechanisms by which exercise increases sympathetic nervous system activity is unclear. This research is designed to examine whether sympathetic nervous system activation alters the ability of muscle to exercise. This study will use the local forearm infusion of an FDA approved drug called Bretylium to temporarily block the release of the chemical norepinephrine. This technique used previously by other researchers is called a Bretylium """"""""Bier Block"""""""".

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
6
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Type
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
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