This is a non-randomized multicenter Phase II Clinical Trial of RSR13, an agent that modifies hemoglobin in a manner similar to 2,3-DPG, to increase the delivery of oxygen to tissues, thereby amplifying tussue oxygenation, Previous experiments have shown that the cell killing effectof radiation therapy is diminished in the presence of hypoxia. Hypoxic conditions are present in tumors and may be a major cause of treatment failure. RSR13 and Oxygen wull be administered to patients with glioblastome multiforme in conjunction with radiation therapy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR010732-06
Application #
6408095
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1995-08-15
Project End
2004-11-30
Budget Start
Budget End
Support Year
6
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Type
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
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