This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this study is to determine whether there are differences in peripheral vascular responsiveness in exercising leg muscles in younger and older subjects when leg blood flow is not limited centrally (i.e. by cardiac output during large muscle-mass dynamic exercise). Additionally, we seek to determine whether age-related changes in peripheral vascular responsiveness are influenced by sex and/or fitness.
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