This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator. The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are abundant in fish and have been found to play an important role in protecting cardiovascular health although the complete mechanisms of action are still poorly understood. Omega-3 fatty acids are effective in lowering triglycerides in a dose-dependent manner and have been shown to have anti-inflammatory and vascular-health-promoting effects in some studies. Omacor is an FDA-approved drug that is a concentrated form of EPA and DHA and is used to lower triglycerides in patients with very high triglycerides (> 500 mg/dL). In this study we will give 1 g and 4 g doses of Omacor to 25 subjects with moderate hypertriglyceridemia (150-500 mg/dL) because they are at elevated risk for heart disease but currently do not receive medical treatment for this form of dyslipidemia. We are using a randomized, placebo-controlled, double-blind, crossover design with three 8-week treatment periods (1 g, 4 g, and placebo) and 6-week washout periods between treatments. Our primary endpoints are measures of physiologic responses to stress and flow-mediated dilation (a measure of endothelial health). Both measures are thought to predict incidence of cardiovascular mortality. We will also measure erythrocyte omega-3 fatty acid concentration (the omega-3 index) and markers of inflammation, and perform a complete lipid panel. We hypothesize that the 4 g dose will lower triglycerides 20-35%, improve stress reactivity and flow-mediated dilation, and possibly result in decreased inflammation. We feel that it is important to study the 1 g dose to provide an evaluation of the upper level of current dietary recommendations; however we cannot predict its effects on our vascular endpoints. Little research has used this more moderate dose even though it is the current recommended daily intake for cardiovascular health based on large intervention and epidemiological studies.
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
| Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208 |
| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917 |
| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Quick, Virginia; Byrd-Bredbenner, Carol; Shoff, Suzanne et al. (2016) Relationships of Sleep Duration With Weight-Related Behaviors of U.S. College Students. Behav Sleep Med 14:565-80 |
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