EXCEED THE SPACEPROVIDED.This is a renewal application for the General Clinical Research Center (GCRC) at the Pennsylvania StateUniversity College of Medicine and The Milton S. Hershey Medical Center (HMC) with satellite outpatientfacilities at the Elmore Clinical Research Center of the Pennsylvania State University (PSU), University Park(UP), PA. The GCRC program was initially funded in August of 1995 and refunded in December of 1999.The GCRC moved into new facilities in March 2003 after obtaining a Construction Grant (COS) from theNCRR in September of 2001. The satellite at the University Park campus is housed in the Elmore ClinicalResearch Center. Over the last 5 year funding period, the unit has grown incorporating a number of wellfunded scientists, expanding services, enhancing research training, and providing our investigators andpatients with two truly outstanding facilities in which to perform their work. This renewal application contains80 protocols from investigators in 27 separate departments within the Pennsylvania State University. Themajor areas of investigation include autonomic and cardiovascular physiology, aging, obesity, polycysticovary disease, the genetics of ARDS, the study of the mechanisms and impact of sleep-disordered breathingon various diseases, the effects of nutrition on cardiovascular risk, and the study of insulin resistance. Weare requesting 7,439 outpatient visits and 0 per diem inpatient days for the GCRC-Hershey, and 4,163outpatient visits and 0 per diem inpatient days for the GCRC-UP. We are also requesting support for theImmunomodulation and Microdialysis Core Laboratories. We are enthused about the growth of the centerand the potential for continued success.
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