This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall purpose of this study is to test the effectiveness of 12 months of increased food intake to improve bone health and restore menstrual cycles in women with menstrual disturbances who exercise regularly and exhibit chronic energy deficiency. We will determine the following: 1) if an increased caloric intake intervention that results in an energy surplus and weight gain in women with Exerciseassociated menstrual disturbances (EAMD) and low to normal bone mineral density (BMD) reverses the deleterious effects of food restriction and negative energy balance on bone outcomes;2) the relative contributions of estrogen-dependent and estrogen-independent pathways to bone outcomes;3) if any improved effects of estrogen status or markers of bone resorption or formation translate into detectable changes in improved bone outcomes, as assessed by serial dual energy x-ray absorptiometry (DXA) and pQCT measurements, that may impact fracture risk;and 4) the relative contribution of changes in body weight, body fat and lean mass to BMD and resumption of menses.
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
| Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208 |
| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917 |
| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Quick, Virginia; Byrd-Bredbenner, Carol; Shoff, Suzanne et al. (2016) Relationships of Sleep Duration With Weight-Related Behaviors of U.S. College Students. Behav Sleep Med 14:565-80 |
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