This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Emotional responses to stress are linked with immune and inflammatory changes, such as changes to inflammatory cytokine profiles, and new research suggests that such changes are implicated in the aggravation of long-term pain. Our overall objective is to examine the impact of emotion on pain and inflammatory responses to pain, as well as the degree to which inflammation and other physiological factors explain associations between emotion, perceived stress, and pain. This will be examined among individuals with rheumatoid arthritis, for whom additional strategies to manage pain are greatly needed and for whom emotional regulation may be particularly important. During each of 3 proposed """"""""emotion"""""""" visits, spaced about 1 month apart, 40 individuals will complete emotion-focusing exercises to elicit either anger, depressed mood, or positive emotion;these visits will be contrasted with a baseline control visit during which emotion is not elicited. During each visit, blood will be drawn at baseline and just before, during, and 30 minutes after a pain threshold test. Blood will be assayed for C-reactive protein (baseline only), and proinflammatory cytokines TNF-a, IL-1, IL-6, anti-inflammatory cytokine interleukin-10 (IL-10), cortisol, and catecholamines. We expect that (1) both state anger and negative mood will increase RA pain severity and, in response to acute pain, will increase cortisol and proinflammatory cytokine responses. Positive emotion will have the opposite effects;(2) Cytokine changes will account for the effects of state emotion on both pain severity from RA and pain threshold.
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
| Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208 |
| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917 |
| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Quick, Virginia; Byrd-Bredbenner, Carol; Shoff, Suzanne et al. (2016) Relationships of Sleep Duration With Weight-Related Behaviors of U.S. College Students. Behav Sleep Med 14:565-80 |
Showing the most recent 10 out of 645 publications
