A tradition of scientific excellence and open collaboration among the faculty will foster the establishment of a new GCRC program at the Albert Einstein College of Medicine-Montefiore Medical Center. The Einstein- Montefiore GCRC will serve a population in the Bronx and Westchester Counties of New York State totaling some 1.9 million people, half from minority racial and ethnic groups. The strong commitment of the two institutions to the GCRC initiative has provided new space and facilitated access to resources for patient-oriented research. The enthusiasm for the GCRC program is demonstrated by the participation of 44 investigators from a total of II departments--both clinical and basic science--who will be involved in the projects described in this application, bringing to bear over $14 million in federally-funded research support. These investigator- initiated projects involve a diverse range of human diseases such as diabetes, tuberculosis, Wilson's disease, liver disease, sickle cell anemia, polycystic kidney disease, systemic lupus erythematosus, infectious diarrhea, obesity, cardiovascular disease, impotence, cervical cancer, and dementia. The projects bring together interdisciplinary research which is principally NIH-funded but which lack adequate resources for clinical studies. The GCRC facilities are located on a single campus in the Bronx; the GCRC administrative, outpatient, sample processing laboratory, and biostatistical components will be located at the College of Medicine and the inpatient per diem admissions and special procedures units at the contiguous University Hospital. A large number of Centers and Shared Scientific Facilities will provide support to GCRC investigators. The Einstein GCRC will provide an environment to conduct human studies and to facilitate data acquisition, management, and analysis, and will encourage collaborations between basic and clinical scientists. Finally, the GCRC will serve as the centerpiece of the Institution's commitment to the training of young physician scientists. The Center's administration will include executive staff from the College of Medicine and Hospital, and the Center will be directed by an experienced group of investigators with previous GCRC experience, basic science expertise and strong independent scientific programs.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR012248-02
Application #
2688956
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1997-09-30
Project End
2001-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Ezzati, Ali; Katz, Mindy J; Lipton, Michael L et al. (2016) Hippocampal volume and cingulum bundle fractional anisotropy are independently associated with verbal memory in older adults. Brain Imaging Behav 10:652-9
Huang, Ying; Van Horn, Linda; Tinker, Lesley F et al. (2014) Measurement error corrected sodium and potassium intake estimation using 24-hour urinary excretion. Hypertension 63:238-44
Mossavar-Rahmani, Yasmin; Tinker, Lesley F; Huang, Ying et al. (2013) Factors relating to eating style, social desirability, body image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative. Nutr J 12:63
Esterson, Yonah B; Zhang, Kehao; Koppaka, Sudha et al. (2013) Insulin sensitizing and anti-inflammatory effects of thiazolidinediones are heightened in obese patients. J Investig Med 61:1152-60
Prentice, Ross L; Neuhouser, Marian L; Tinker, Lesley F et al. (2013) An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 22:2374-83
Wylie-Rosett, Judith; Aebersold, Karin; Conlon, Beth et al. (2013) Health effects of low-carbohydrate diets: where should new research go? Curr Diab Rep 13:271-8
Cai, Guiqing; Atzmon, Gil; Naj, Adam C et al. (2012) Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease. Neurobiol Aging 33:416-417.e3
Wang, Zhaoming; Parikh, Hemang; Jia, Jinping et al. (2012) Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry. Hum Genet 131:1173-85
Kenny, Eimear E; Pe'er, Itsik; Karban, Amir et al. (2012) A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS Genet 8:e1002559
Kehlenbrink, S; Koppaka, S; Martin, M et al. (2012) Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis. Diabetologia 55:3021-8

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