This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project has developed optimal approaches to the reproducible magnetic resonance study of the hippocampus for imaging and spectroscopic studies. In particular, repeated and longitudinal evaluation of the hippocampus is important for studies in epilepsy and aging, amongst other neurological diseases. Thus this project has developed wholly obliqued imaging together with analysis software to co-register and consistently evaluate hippocampal metabolism in a semi-automated fashion. While the literature demonstrates 10-20% CV in whole hippocampal studies, demonstration of the obliqued-co-registered approach in n=10 control volunteers (each studied twice) provide a standard deviation of difference of 9% for individual hippocampal voxels and 3.5% over the entire hippocampus. This work has been accepted as a platform discussion to the Int'l Society for Magnetic Resonance 2004 and has been submitted Magn Res Medicine, citing the GCRC.
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