Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Epidemiologic and biologic evidence support an association between chronic hepatitis C infection and type 2 diabetes mellitus. However whether clearance of hepatitis C virus (HCV) is associated with improved glucose metabolism is not known. To address this issue, we propose a 2-year prospective study of individuals initiating therapy for chronic hepatitis. C infection.
The specific aim of the project is: To determine the effects of hepatitisC treatment on glucose tolerance, insulin resistance, and insulin secretion.Participants will undergo research visits 1 week prior to initiating hepatitis C therapy and every 3 months during therapy. Each visit will consist of a standardized interview, 'anthropometry, and a 2-hour oral glucosetolerance test with insulin levels. Additional clinical data will be obtained, following written informed consent, from medical records.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR012248-11
Application #
7608080
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Project Start
2007-02-15
Project End
2007-11-30
Budget Start
2007-02-15
Budget End
2007-11-30
Support Year
11
Fiscal Year
2007
Total Cost
$729
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Ezzati, Ali; Katz, Mindy J; Lipton, Michael L et al. (2016) Hippocampal volume and cingulum bundle fractional anisotropy are independently associated with verbal memory in older adults. Brain Imaging Behav 10:652-9
Huang, Ying; Van Horn, Linda; Tinker, Lesley F et al. (2014) Measurement error corrected sodium and potassium intake estimation using 24-hour urinary excretion. Hypertension 63:238-44
Mossavar-Rahmani, Yasmin; Tinker, Lesley F; Huang, Ying et al. (2013) Factors relating to eating style, social desirability, body image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative. Nutr J 12:63
Esterson, Yonah B; Zhang, Kehao; Koppaka, Sudha et al. (2013) Insulin sensitizing and anti-inflammatory effects of thiazolidinediones are heightened in obese patients. J Investig Med 61:1152-60
Prentice, Ross L; Neuhouser, Marian L; Tinker, Lesley F et al. (2013) An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 22:2374-83
Wylie-Rosett, Judith; Aebersold, Karin; Conlon, Beth et al. (2013) Health effects of low-carbohydrate diets: where should new research go? Curr Diab Rep 13:271-8
Cai, Guiqing; Atzmon, Gil; Naj, Adam C et al. (2012) Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease. Neurobiol Aging 33:416-417.e3
Wang, Zhaoming; Parikh, Hemang; Jia, Jinping et al. (2012) Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry. Hum Genet 131:1173-85
Kenny, Eimear E; Pe'er, Itsik; Karban, Amir et al. (2012) A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS Genet 8:e1002559
Kehlenbrink, S; Koppaka, S; Martin, M et al. (2012) Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis. Diabetologia 55:3021-8

Showing the most recent 10 out of 150 publications