This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Crigler-Najjar syndrome types I and II are autosomal recessively inherited disorders that results in chronic nonhemolytic unconjugated hyperbilirubinemia. These disorders are caused by the presence of genetic lesions within the coding regions of the bilirubin UGT gene (UGT1A1) which completely or partially inactivate the B-UGT enzyme activity. Gilbert syndrome on the other hand is caused by the promoter abnormality of UGT gene (UGT1A1). In normal subjects, the promoter of UGT gene contains the sequence A(TA)6TAA. The Gilbert patients are homozygous for two extra bases (TA) in the promoter region, A(TA)7TAA. The presence of the longer TATAA element resulted in the reduced expression of the enzyme.
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