This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.'Atherosclerosis, bone loss, drug use, and HIV in older men' is a five-year prospective study of the effects of HIV and drug use on aging and its sequelae in middle-aged men in the Bronx, New York City. A cohort of men with or at risk for HIV infection, including drug users and men with a history of high-risk sexual contact, has been assembled. A subset of these men (N=240) is being enrolled in the 'Diabetes and Lipids in Men Substudy', to assess the effects of HIV infection and highly active antiretroviral therapy (HAART) on dyslipidemia, insulin resistance, and the development of atherosclerosis. We are targeting substudy enrollment such that: 1) 90 men are HIV-negative; 2) 40 are HIV-infected but antiretroviral na ve; 3) 40 are HIV-infected, on HAART, but protease inhibitor (PI) na ve; and 4) 70 are HIV-infected and on HAART including a PI. Men with a history of diabetes mellitus are ineligible for substudy enrollment. Substudy participants will undergo two fasting research visits at the GCRC over a three year period, at which a 2-hour oral glucose tolerance test (OGTT) and lipid profile will be performed. The participants will also undergo two carotid ultrasounds to assess subclinical atherosclerosis.
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