Abstract

A significant inherited susceptibility locus for non-insulin dependent diabetes (NIDDM) is suggested by a high concordance in identical twins, strong familial aggregation, and evidence from segreagation analysis for a major gene for both the disease and intermediate phenotypes. Despite extensive study, no predisposing biochemical defect has been identified conclusively. Known loci explain <1% of inherited diabetes. The positional search strategy offers a powerful alternative approach to identify diabetes susceptibility genes and to understand the early stages of NIDDM pathophysiology. We hypothesize that NIDDM susceptibility is determined by a locus with major clinical impact in an oligogenic disease model, and that this locus will result in an identifiable phenotypic subgroup of pedigrees with a strong family history of NIDDM onset before age 65.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR014288-02
Application #
6406578
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1999-08-01
Project End
2003-11-30
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205

  Publications

Serra, Monica C; Blumenthal, Jacob B; Addison, Odessa R et al. (2017) Effects of Weight Loss with and without Exercise on Regional Body Fat Distribution in Postmenopausal Women. Ann Nutr Metab 70:312-320
Grams, Morgan E; Yang, Wei; Rebholz, Casey M et al. (2017) Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 70:337-346
Coker, Robert H; Hays, Nicholas P; Williams, Rick H et al. (2015) Bed rest promotes reductions in walking speed, functional parameters, and aerobic fitness in older, healthy adults. J Gerontol A Biol Sci Med Sci 70:91-6
Coker, Robert H; Hays, Nicholas P; Williams, Rick H et al. (2014) Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults. J Gerontol A Biol Sci Med Sci 69:363-70
Herrick, Jeffrey E; Bliwise, Donald L; Puri, Shipra et al. (2014) Strength training and light physical activity reduces the apnea-hypopnea index in institutionalized older adults. J Am Med Dir Assoc 15:844-6
Conley, Travis B; McCabe, George P; Lim, Eunjung et al. (2013) Age and sex affect protein metabolism at protein intakes that span the range of adequacy: comparison of leucine kinetics and nitrogen balance data. J Nutr Biochem 24:693-9
Mondal, Ashis K; Sharma, Neeraj K; Elbein, Steven C et al. (2013) Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility. Physiol Genomics 45:509-20
Sharma, Neeraj K; Langberg, Kurt A; Mondal, Ashis K et al. (2013) Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. PLoS One 8:e65303
Lorenz, Rebecca A; Gooneratne, Nalaka; Cole, Catherine S et al. (2012) Exercise and social activity improve everyday function in long-term care residents. Am J Geriatr Psychiatry 20:468-76
Thrailkill, K M; Jo, C-H; Cockrell, G E et al. (2012) Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes. Osteoporos Int 23:1799-806

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