Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to comprehensively examine the influence of caloric restriction (weight loss) and exercise training (with and without weight loss) on hepatic and peripheral insulin resistance in persons with IGT during a 24 week, randomized, controlled trial. We will utilize a somatostatin, multi-stage, euglycemic clamp technique to specifically examine hepatic and peripheral insulin action. Overall, these studies will be the first to systematically identify the influence of diet and exercise on the pathogenic factors (hepatic and peripheral insulin resistance) that contribute to Type 2 diabetes and CVD

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR014288-08
Application #
7377672
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-04-01
Project End
2007-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
8
Fiscal Year
2006
Total Cost
$24,209
Indirect Cost

  Institution

Name
University of Arkansas for Medical Sciences
Department
Type
Schools of Medicine
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205

  Publications

Serra, Monica C; Blumenthal, Jacob B; Addison, Odessa R et al. (2017) Effects of Weight Loss with and without Exercise on Regional Body Fat Distribution in Postmenopausal Women. Ann Nutr Metab 70:312-320
Grams, Morgan E; Yang, Wei; Rebholz, Casey M et al. (2017) Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 70:337-346
Coker, Robert H; Hays, Nicholas P; Williams, Rick H et al. (2015) Bed rest promotes reductions in walking speed, functional parameters, and aerobic fitness in older, healthy adults. J Gerontol A Biol Sci Med Sci 70:91-6
Coker, Robert H; Hays, Nicholas P; Williams, Rick H et al. (2014) Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults. J Gerontol A Biol Sci Med Sci 69:363-70
Herrick, Jeffrey E; Bliwise, Donald L; Puri, Shipra et al. (2014) Strength training and light physical activity reduces the apnea-hypopnea index in institutionalized older adults. J Am Med Dir Assoc 15:844-6
Conley, Travis B; McCabe, George P; Lim, Eunjung et al. (2013) Age and sex affect protein metabolism at protein intakes that span the range of adequacy: comparison of leucine kinetics and nitrogen balance data. J Nutr Biochem 24:693-9
Mondal, Ashis K; Sharma, Neeraj K; Elbein, Steven C et al. (2013) Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility. Physiol Genomics 45:509-20
Sharma, Neeraj K; Langberg, Kurt A; Mondal, Ashis K et al. (2013) Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. PLoS One 8:e65303
Lorenz, Rebecca A; Gooneratne, Nalaka; Cole, Catherine S et al. (2012) Exercise and social activity improve everyday function in long-term care residents. Am J Geriatr Psychiatry 20:468-76
Thrailkill, K M; Jo, C-H; Cockrell, G E et al. (2012) Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes. Osteoporos Int 23:1799-806

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