This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Trial to Assess Chelation Therapy (TACT) is a 5-year randomized, double-blind, placebo-controlled 2X2 factorial trial designed to test the effects of the standard chelation solution recommended by the American College for Advancement in Medicine (ACAM), as well as the effects of a high-dose antioxidant vitamin and mineral supplementation, versus a low dose regimen to simply replace chelation-related losses.
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