This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sixty-four percent of all Americans are overweight or obese. Many attempt weight loss with low carbohydrate ketogenic (LCK) diets that have been popularized by the media and physicians like Dr. Robert Atkins. LCK diets have not been proven to be safe or effective. The intent of this study is to test the safety of the LCK diet and compare efficacy with a balanced low calorie diet plan that is consistent with the USDA Dietary Guidelines. In this study, 64 healthy, obese men and women with Body Mass Index between 30 and 40 kg/m2 will be randomly assigned to either the LCK or a balanced diet plan in a two arm randomized clinical trial with repeated measures over time. During the first three months of the study, all subjects will be followed weekly by attendance at a group education session during which a meal consistent with their assigned diet protocol will be served. During the last 3 months of the study, follow-up at group sessions will occur monthly. Differences will be assessed between baseline mean, the first 3-month period mean, and the 6-month period mean for weight, body fat and lean tissue, blood glucose and lipids, blood urea nitrogen, creatinine, uric acid, and a validated quality of life questionnaire. Resting energy expenditure will be assessed seven times over the course of the trial.
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