This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is the doctoral dissertation of Sharmila Nabar (Advisor: Randall E. Keyser, Ph.D.). the project is being completed in partial fulfillment of the requirements for the Docator of Philosophy in Physical Rehabilitation Science. My (Sharmila Nabar) broad objective is to comprehend the underlying mechanisms that determine the oxygen on-kinetics response to step increases in energy demand.Knowledge of oxygen uptake on-kinetics is vital to understand physiological mechanisms underlying the metabolic adjustments that occur during sustained muscular exercise. These control mechanisms may be useful in predicting exercise performance in athletes and also in individuals with an impairment of the oxidative metabolic system.
The specific aims of my research are as follows:
Specific Aim 1 :To determine how diffusion gradient changes effect matching of energy supple and demand above and below the gas exchange threshold.
Specific Aim2 :To determine how a change in the oxygen diffusion gradient affects the slow component of the oxygen on-kinetics curve above the ventilatory threshold in normal untrained individuals.
Specific Aim3 :To determine how the slow and fast response of the oxygen kinetics curves relate to fatigue resistance. Thirty healthy and sedentary individuals will be recruited for the study. These subjects will undergo a maximal cycle ergometer test and a series of cycle ergometer tests at sub-maximal intensities while breathing varying fractional concentrations of oxygen. The change in the inspired frcation of oxygen will affect the peripheral diffusion gradient. The indices of the oxygen on-kinetics curve during these tests will then be examined and compared to elucidate the mechanisms that govern the fast and the slow components pf the oxygen uptake curve.
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