This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This study investigates the hypothesis that in chronic stroke patients a 6-month program of TM exercise progressed on the parameter of training velocity will optimize gains in CV fitness, compared to a duration-based training progression that will optimize gains in ambulatory function. In addition, we compare these treatment groups to a reference control group that recieves supervised stretching exercises (a common component to conventional care) Aims: 1. Determine the effects of velocity versus duration based training on CV fitness in stroke patients by measuring peak exercise capacity, cardiac output, and kinetics of oxygen consumption during treadmill exercise testing with open circuit spirometry. 2. Determine the effects of velocity vs. duration based training on ambulatory function measured by timed walks, gait biomechanics, and free-living ambulatory activity levels, and whether changes in ambulatory function are related to brain neuroplasticity measured by BOLD fMRI of P knee movement. 3. Determine the temporal profile and durability of treatment effects according to training strategy by repeated measures of fitness and ambulatory function outcomes after 3- and 6-months training, and 6 months following training cessation.
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