This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infliximab has recently emerged as a powerful treatment for Crohn's disease patients who are unresponsive to the traditional immunosuppressive therapies. Many of these Crohn's disease patients suffer from severe malnutrition due to a variety of disease related factors. Current literature acknowledges 1) that Crohn's disease patients suffer from several nutritional deficiencies and 2) that Crohn's disease patients have had significant clinical responses to infliximab therapy. However, there are no studies which have looked for a nutritional response to Crohn's disease patients beginning this therapy. This study addresses the issue of nutritional changes in Crohn's patients throughout the initial infliximab treatment. We hypothesize that infliximab treatment will improve various nutritional parameters in the subjects and that these improvements will increase with further dosing of infliximab.
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