This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Foot disease complications seriously impact lives of people with diabetes. A quantitative method to evaluate efficacy of therapy, or better, to define tissue at risk & prevent initial ulcer formation would be highly beneficial. This study, part of a multicenter study by HyperMed Inc. (STTR, funded by the NIH) has a long-term objective to reduce frequency of foot ulceration by developing Medical HyperSpectral Imaging (MHSI). The MHSI camera-based system (manufactured by HyperMed, Inc.) is used in this study to identify tissue at risk for ulceration, evaluate the healing capability of an ulcer & monitor treatment efficacy. MHSI provides an image with spectral data inherent in each pixel which reflects the presence & concentration of various chemical species.
Specific aims of this study are to: 1) assess healing or progression in 10 type 1 and 12 type 2 diabetic patients with manifest foot ulcers, 2) study 30 type 1 and 40 type 2 diabetic patients at high risk for foot ulceration in a longitudinal study aimed at predicting ulceration, 3) validate merit in further developing MHSI using clinical outcome measures & comparing MHSI with existing methods (TcPO2) to determine advantages & limitations of MHSI in clinical foot care. MHSI is potentially a cost effective, easy to use, turn-key camera-based tool, which delivers metabolic information in a simple to interpret image. It will positively impact the quality of life of people with diabetes, impacting morbidity & mortality & lowering overall healthcare costs.
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