This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The primary objective of the Clinical Core (Core B) will be to provide a well-characterized cohort of subjects with autism and autism spectrum disorders and non-autistic control subjects for enrollment in research projects and collaborative endeavors of the Greater New York Autism Research Center of Excellence (GNY-ARCE). Core B will acquire comprehensive clinical and laboratory data through 'gold standard' diagnostic, functional, cognitive, developmental, and adaptive evaluation, and through exhaustive interviews including birth history, medical history and screening. In addition, Core B will collect genetic samples from autistic and autism spectrum subjects as well as family members and control/comparison subjects. Core B will provide rigorous baseline evaluation to assess diagnostic eligibility and cognitive ability and to characterize core symptom domains for inclusion in Projects I (Genetics; Buxbaum, PI), II (Imaging; Laruelle, PI), and III (Psychopharmacology; Hollander, PI). Additionally, Core B will offer longitudinal evaluation to collect information from autistic subjects concerning course of illness and development of comorbid disorders that will allow for exploratory analyses and involvement with future research.
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