This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The cholinergic anti-inflammitory pathway is a mechanism through which the autonomic nervous system, specifically the vagus nerve, regulates the host inflammatory response. In this protocol we will investigate the effect of transcutaneous stimulation of the auricular branch of the vagus nerve on vagal tone, as measured by heart rate variability. We will study the magnitude of response obtained with different stimulation location, duration, and technique, as well as the impact of circadian rhythm. This information will provide us with the optimal stimulation parameters for use in future trials looking at the effect of transcutaneous vagus stimulation on inflammatory disease.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR018535-06
Application #
7719287
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-04-22
Project End
2009-03-31
Budget Start
2008-04-22
Budget End
2009-03-31
Support Year
6
Fiscal Year
2008
Total Cost
$12,892
Indirect Cost
Name
Feinstein Institute for Medical Research
Department
Type
DUNS #
110565913
City
Manhasset
State
NY
Country
United States
Zip Code
11030
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