This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Objectives: The objectives of this study are to determine the optimal dose (21 mg or 14 mg) and duration (24 hours or 16 hours) of nicotine replacement using the nicotine transdermal delivery device for African-American pregnant women who smoke, and to determine the implications of the nicotine replacement studies for treatment with the nicotine replacement patch of African-American women who smoke during pregnancy and safety and treatment with the nicotine replacement patch for their fetus.Anticipated Results: The primary outcome will be comparison of the peak nicotine level achieved using the nicotine patch to the nicotine level achieved by ad lib smoking. This outcome is important to the consideration of the nicotine patch as a standard treatment for pregnant women who smoke. Other outcomes will include comparison of the pharmacokinetics of nicotine delivered by smoking to nicotine delivered by the patch. Comparison of the pharmacokinetics of nicotine and cotinine metabolism in African-American women to Caucasisan women will be made.
Showing the most recent 10 out of 203 publications
