The objectives of this contract are to develop, maintain and distribute large quantities of extensively characterized cell cultures relevant to the conduct of research of aging. These include specially characterized diploid human fetal lung fibroblast lines (IMR-90, IMR-91, WI-38, TIG-1, and MRC-5); cultures from selected members of extensive pedigrees with familial Alzheimer's disease; normal human non-fetal fibroblast cultures derived from participants in the Baltimore Longitudinal Study over a span of ages from 17 to 96 years of age; cultures from individuals with segmental progeroid syndromes (Werner's, Hutchinson-Gilford, Cockayne, and Rothmund-Thomson); various nonhuman skin fibroblasts including nonhuman primates from 8 days to 27 years of age. Emphasis in recent years has been on development of fibroblast and endothelial cell cultures from the same donors, both human and nonhuman.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research and Development Contracts (N01)
Project #
N01AG012101-002
Application #
2294044
Study Section
Project Start
1991-02-01
Project End
2000-01-31
Budget Start
1992-01-30
Budget End
1993-01-31
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Coriell Institute for Medical Research
Department
Type
DUNS #
069894707
City
Camden
State
NJ
Country
United States
Zip Code
08103
Blazer, Dan G; Fillenbaum, Gerda G; Gold, Deborah T et al. (2003) APOE epsilon4 as a predictor of subjective quality of life in a biracial older person community sample. J Aging Health 15:645-60
Toji, L H; Lenchitz, T C; Kwiatkowski, V A et al. (1998) Validation of routine mycoplasma testing by PCR. In Vitro Cell Dev Biol Anim 34:356-8
Cristofalo, V J; Allen, R G; Pignolo, R J et al. (1998) Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. Proc Natl Acad Sci U S A 95:10614-9