Abstract

The NIAID multicenter Mycoses Study Group has designed multiple Phase I, II, and III clinical studies to evaluate the efficacy and toxicity of various single and multiple drug regimens for the therapy of cryptococcal meningitis and various forms of aspergillosis, coccidioidomycosis, blastomycosis, histoplasmosis, and candidiasis. Currently accepted """"""""standard"""""""" regimens will be compared against innovative new regimens. The ultimate goals of these activities are to improve therapy of the systemic mycoses and to reduce morbidity and associated health care costs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI052562-007
Application #
3594514
Study Section
Project Start
1984-11-08
Project End
1989-10-07
Budget Start
1986-10-07
Budget End
1987-10-07
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Dismukes, William E (2006) Antifungal therapy: lessons learned over the past 27 years. Clin Infect Dis 42:1289-96
Sharkey-Mathis, P K; Kauffman, C A; Graybill, J R et al. (1993) Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group. Am J Med 95:279-85
Powderly, W G; Saag, M S; Cloud, G A et al. (1992) A controlled trial of fluconazole or amphotericin B to prevent relapse of cryptococcal meningitis in patients with the acquired immunodeficiency syndrome. The NIAID AIDS Clinical Trials Group and Mycoses Study Group. N Engl J Med 326:793-8
Fish, D G; Ampel, N M; Galgiani, J N et al. (1990) Coccidioidomycosis during human immunodeficiency virus infection. A review of 77 patients. Medicine (Baltimore) 69:384-91
Graybill, J R; Stevens, D A; Galgiani, J N et al. (1990) Itraconazole treatment of coccidioidomycosis. NAIAD Mycoses Study Group. Am J Med 89:282-90
Dismukes, W E; Wade, J S; Lee, J Y et al. (1990) A randomized, double-blind trial of nystatin therapy for the candidiasis hypersensitivity syndrome. N Engl J Med 323:1717-23
Sugar, A M; Alsip, S G; Galgiani, J N et al. (1987) Pharmacology and toxicity of high-dose ketoconazole. Antimicrob Agents Chemother 31:1874-8
Dismukes, W E; Cloud, G; Gallis, H A et al. (1987) Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks. N Engl J Med 317:334-41