This proposed has research the following major objectives: (1) determine the risk of perinatal transmission of Human Immunodeficiency Virus (HIV) to th fetus in women who are asymptomatic but HIV antibody positive, women with AIDS Related Complex (ARC), and women with Acquired Immunodeficiency Syndrome (AIDS); (2) determine the effect of pregnancy on the natural history of HIV infection in women as related to known risk factors; (3) determine the effect of maternal HIV infection on the outcome of pregnancy; (4) determine the natural history of HIV infection in neonates, infants, and children. Additional objectives for which answers will be sought include: (1) to determine the rate of seroconversion from HIV antibody negative to HIV positive in a cohort of nonpregnant women as well as pregnant women who are at risk for acquiring HIV infection; (2) determine the risk and rate of neurodevelopmental defects in HIV negative and positive children being studied; and (3) determine the risks and rate of neuropsychiatric defects in HIV negative and positive women in the study.
| McIntosh, K; Comeau, A M; Wara, D et al. (1996) The utility of IgA antibody to human immunodeficiency virus type 1 in early diagnosis of vertically transmitted infection. National Institute of Allergy and Infectious Diseases and National Institute of Child Health and Human Development Women and Infants Arch Pediatr Adolesc Med 150:598-602 |
| Landay, A L; Brambilla, D; Pitt, J et al. (1995) Interlaboratory variability of CD8 subset measurements by flow cytometry and its applications to multicenter clinical trials. NAID/NICHD Women and Infants Transmission Study Group. Clin Diagn Lab Immunol 2:462-8 |
| Sheon, A R; Fox, H E; Alexander, G et al. (1994) Misdiagnosed HIV infection in pregnant women: implications for clinical care. Public Health Rep 109:694-9 |
